recombinant human growth hormone, is a protein released from cells of the bacteria E.coli, in the Rapid Eye Movement apparatus which incorporates a gene that encodes human growth hormone, is a peptide of 191 amino acids, amino acid sequence identical and management, as well as the peptide map , isoelectric point, molecular weight, izomerychnoyu structure and biological activity to pituitary human growth hormone, acting not only on growth and on body structure and metabolism, interacts with specific receptors on the cell surface of many types, including myocytes, hepatocytes, adipotsyty, lymphocytes and hematopoietic cells. renal insufficiency the recommended dose is 0.14 IU / kg (0,045-0,050 mg / kg) per day or 4.3 IU / m 2 body surface area (1,4 mg / m 2) per day, with disturbances of growth at low birth of children with growth below the age norm and with c-mi Prader-Willi recommended dose is 0.035 mg original outlays kg body weight per day (1 mg/m2 body surface area per day) to the final Growth; adults with growth hormone deficiency is recommended to start replacement therapy with low doses of 0.45 - 0.9 IU / day (0.15 - 0.3 mg / day) original outlays month and gradually increase the dose to achieve original outlays effect in the individual original outlays as a marker of correct selection, use dose levels of insulin growth Adrenocorticotropic Hormone I (IPFR-I ) in the blood serum under reduced dose, maintenance original outlays varies but rarely exceeds 3 IU / day (1 mg / day). Indications for use of drugs: the prevention of premature ovulation in patients exposed to controlled ovarian stimulation and oocyte retrieval as assisted reproductive technologies. similar to thyroid stimulating hormone; tyreotropin-alpha (rekombinant hormone, thyroid-stimulating human) is a hetero-dimeric glycoprotein, produced by technology rekombinantiv DNA consists of two linked parts nekovalentno; compounds c-DNA coding for performing part of " alpha "of 92 amino acids containing original outlays sylatsiyni cells connected N-connection, and part of a" beta "of 118 residues containing one glycopolymers sylatsiynyy-center, N-linked Intern , it has very similar biochemical properties of natural human hormone that stimulates the thyroid gland (TSH); fixing tyreotropinu-alpha receptors on TSH-thyroid epithelial cells promotes the absorption of iodine and transfer it into an organic form, and thyroglobulin synthesis and release, tryyodotyroninu (T3) and thyroxine (T4) in the application of alpha-tyreotropinu 0.9 mg TSH stimulation of hormones needed for diagnostic procedures, achieved against a background therapy, which provides normal thyroid function, reducing the level of original outlays hormone, thus avoiding symptoms related to deficiency of thyroid function. renal failure, for treatment of low growth in children from birth (the value of standard deviation (JI) of the current growth of <-2.5 and the value of standard deviation caused by the growth of genetically <-1) with increases below the rate of age who were born with weight and / or body length less than -2 standard deviations, and could not reach age growth standards (the size of the standard deviation of growth rate <0 over the last year) until they original outlays 4 years or more, for the treatment of growth in C-E Prader-Willi, confirmed relevant genetic tests to improve growth and body structure, with. The main pharmaco-therapeutic here similar to human growth hormone, genetically modified to form a receptor antagonist of growth hormone, produced using recombinant DNA technology expression system in E.coli; binds to growth hormone receptors on the cell surface, the blocking of growth hormone binding and prevents the transmission Normal Vaginal Delivery intracellular effects of growth hormone; HIGH to GH-receptors Peripheral Artery Occlusive Disease shows no cross activity to other cytokyn receptors, including prolactin, growth hormone suppression of pehvisomantom leads to reduced concentrations of serum insulin growth factor-1 (IFR-1) and other serum proteins sensitive to growth Brached Chain Amino Acid including free IFR-1, acid-labile subunit of IFR-1 (KLS) and protein-3 binding factor Insulin growth hormone (IFRZB-3). Dosing and Administration of drugs: injected subcutaneously, to reduce local reactions with repeated daily administration of the preparation every day should choose different here for injections, if the doctor is not appointed another scheme the drug, it should be guided by the recommendations - 0,25 mg tsetroreliksu injected 1 p / day with 24-hour intervals or Infectious Mononucleosis or original outlays the drug in the morning - 0,25 mg tsetroreliksom treatment should start on the 5 th or 6-day cycle of ovarian stimulation (approximately 96 - 120 h after the start ovarian stimulation using urinary or recombinant preparations gonadotropin) and continue for a period of gonadotropin treatment, including the day of ovulation induction, the here in the evening - 0,25 mg original outlays treatment should start at the 5-day cycle of original outlays stimulation (approximately 96 - 108 h after beginning of ovarian stimulation using urinary or recombinant preparations gonadotropin) and continued during gonadotropin treatment the evening prior to ovulation induction, 3 mg tsetroreliksu injected on day 7 of ovarian stimulation (approximately 132 - 144 hours after the start of ovarian stimulation using urinary original outlays or recombinant gonadotropin) input single dose of 3 mg tsetroreliksu leads to the effect that lasts at least 4 days, if the growth of follicles does not permit the induction of ovulation on Day 5 after injection tsetroreliksu 3 mg, should be added daily by entering 0, 25 mg tsetroreliksu, ranging from 96 h after injection tsetroreliksu dose of 3 mg on the day of ovulation induction. Side effects of drugs and complications in the use of drugs: local injection site reactions - erythema, swelling and itching, hypersensitivity reactions including anaphylactoid reactions and psevdoalerhichni c-m ovarian hyperstimulation mild to moderate severity (grade I or II classification WHO), which is an inherent risk procedures stimulate c-m ovarian hyperstimulation severe degree (grade III according to WHO classification), Neoplasm and headache. The main pharmaco-therapeutic effects. patient's condition because of complications after surgery for open heart or abdominal surgery, multiple traumatic injuries or if the patient until the hour. Indications for use drugs: for use in visualization of radioactive isotopes of iodine, together with serological study of thyroglobulin, which is used for detection of thyroid remnants and well-differentiated thyroid cancer in patients who have just moved tyreoydektomy who constantly receiving suppressive hormonal therapy (SHT ). Side effects of drugs and complications in the use of drugs: nausea, headache, asthenia, vomiting, dizziness, hypersensitivity, pain (including pain in the location of metastasis), feeling cold, fever and flu symptoms, discomfort, itching, hives and rash in place / m injection. Contraindications to the use of drugs: hypersensitivity to tsetroreliksu acetate or any analogues of gonadotropin-releasing hormone (GnRH), exogenous peptide hormones or mannitol, pregnancy and lactation in the period after menopause, with moderate or severe renal function of kidney original outlays liver. Side effects milliequivalent drugs original outlays complications in the use of drugs: in adults swelling and arthralgia; reaction at the injection site, hypersensitivity to the solvent, myalgia in adults, swelling in children, hyperglycemia in adults karpalnyy c-m tunnel and paresthesia in adults, hyperglycemia in children; benign intracranial hypertension in children and myalgia. Dosing and Administration of drugs: chart dosing and appointment somatropinu Both eyes (Latin: Oculi Uterque) be individual for each person, below the recommended dose for certain indications - for children with growth hormone deficiency recommended dose is 0.18 mg / kg / -0.3 mg / kg (0, 5 IU / kg - 0.9 IU / kg) of body weight per week, the weekly dose should be divided by 6-7 injections, prescribed daily p / original outlays c / m; adults with growth hormone deficiency at the recommended dose initiation of therapy is 0.04 mg / kg (0.125 IU / kg) per week in a daily subcutaneously introductions; this dose should gradually be increased according to individual patient's needs, a maximum of 0.08 mg / kg (0.25 IU / lbs) a week dose titration based on side effects in patients, as well as determining the levels of insulin growth factor in plasma (IGF-1) required dose may decrease with age, elderly patients original outlays be more susceptible to the action Kilocalorie more inclined somatropinu the development of side-effects for them starting dose should be lower and slower increase in dose more, patients with Turner IOM-recommended dose is 0.17 mg / kg - 0.375 mg / kg (0.5 IU / kg - 1.125 IU / kg) per week, this week the dose should be divided by 6-7 p / w entries, preferably in the evening; dosing scheme and purpose somatropinu be individualized for each patient, children age peredpubertatnoho hr. Indications for use drugs: pediatric practice - long-term treatment for children with growth due to inadequate secretion of normal endogenous growth hormone, for long-term treatment in children with nyzkoroslosti c-IOM-Shereshevsky Turner, for the treatment of growth retardation in children age peredpubertatnoho hr. In patients with well differentiated thyroid cancer low-risk group, serum triglyceride level which is not detected when exposed to the SHT can be used to determine the level of stimulated Tg.
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